Epithalamus in the human brain

















EPITHALAMUS :-

The Epithalamus occupies the caudal part of the roof of the diencephalon and consists of
1.      The right and left habenular nuclei, each situated beneath the floor of the corresponding habenular trigone.












2.      The pineal body or epiphysis cerebri
3.      The  habenular commissure
4.      The posterior commissure .

HABENULAR NUCLEUS :-

1.      The nucleus lies beneath the floor of the habenular trigone.
2.      The trigone is a small, depressed triangular area, situated above the superior colliculus and medial to the pulvinar of the thalamus.
3.      Medially it is bounded by the stria medullaris thalami and the stalk of the pineal body.
4.      The habenular nucleus forms a part of the limbic system.

PINEAL BODY :-

1.      The pineal body is a small, conical organ, projecting backwards and downwards between the two superior colliculi.
2.      It is placed below the splenium  of the corpus callosum, but is separated from it by the tela choroidea of the third ventricle and the contained cerebral veins.
3.      It consists of a conical body about 8 mm long, and a stalk or peduncle which divides anteriorly into two laminae separated by the pineal recess of the third ventricle.
4.      The superior lamina of the stalk contains the habenular commissure and the inferior lamina contains the posterior commissure.

Morphological significance :-

In many reptiles the epiphysis cerebri is represented by a double structure.
1.      The anterior part (parapineal organ) develops into the pineal or parietal eye.
2.      The posterior part is glandular in nature.
3.      The human pineal body represents the persistent posterior glandular part only.
4.      The parietal eye has disappeared.

STRUCTURE :-













1.      The pineal gland is composed of two types of cells, pinealocytes and neuroglial cells, with a rich network of blood vessels and sympathetic fibres.
2.      The vessels and nerves enter the gland through the connective tissue septa which partly separate the lobules.






3.      Sympathetic ganglion cells may be present.
4.      Calcareous concretions are constantly present in the pineal after the 17th year of life and may form aggregtions  (brain sand). Spaces or cysts may also be present.

FUNCTIONS :-

1.      The pineal body has for long been regarded as a vestigial organ of no importance.
2.      Recent investigations have shown that it is an endocrine gland of great importance.
3.      It produces hormones that may have an important regulatory influence on many other endocrine organs  ( including the adenohypophysis , the neurohyphysis, the thyroid , the para thyroids, adrenal  cortex and medulla, and the gonads).
4.      The best known hormone is melatonin which causes changes in skin colour in some species.
5.      The synthesis and discharge of melatonin is remarkably influenced by exposure of the animal to light. 



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